Factors affecting time until myocardial infarction in hypertension patients using truncated Cox regression

Background and aims: Hypertension is one of the most common and important risk factors of cardiovascular diseases. This phenomenon,if not cured, causes lots of problems in vital organs of the body like kidneys, brain, eyes, and heart. The aim of the current study was toidentify factors which affect the time until myocardial infarction (MI) in hypertension patients using truncated Cox regression.Methods: This study was a population retrospective cohort and its statistical population included patients with hypertension symptoms,who had MI for the first time in Sari. A decision was made based on continuing the study as a nested case and control study because thenumber of MI incidents was low (۷%) in the studied sample. In addition, the Cox’s model and truncated Cox were used for determiningthe factors affecting the patients’ survival.Results: The median and mean survival times in this sample were equal to ۵۷ and ۶۶.۴۴ months, respectively. Considering time truncation,family history (HR=۱.۷۰) and the age at diagnosis (HR=۰.۹۹) were statistically significant in the Cox’s model (P< ۰.۰۵).Conclusion: Overall, using the Akaike criterion for comparing the survival time without the effect of truncation, the Cox’s modeldemonstrated better fitness by controlling the truncation effect. These results show the importance of controlling the truncation in thosediseases in which it is impossible to distinguish the time of the appearance from the symptoms.

کلیدواژه ها:

Hypertension ، Truncated Cox regression ، Myocardial infarction ، Survival time