A ZnO-nanoparticle-promoted synt hesis of oxazole derivatives

Zinc o xide nanoparticles (Zn O NPs) hav e great pote ntial for use as a cataly st for a vari ety of organic and inorganic reactio ns due to th eir high surface-to-volu me ratio [۱]. Also, since ZnO NPs are often rec overed easil y by simple workups, which prevents contamination of pro ducts, they m ay be considered as a promising safe and reusable catalyst. Zinc oxide nanoparticles are used as an effective and r eusable catalyst for one-pot, three-compone nt couplin gs of ammonium thiocy anate, acyl chloride and phenacylbromide to pr oduce oxazole derivati ves at room temperature. Compared with other methods, sa tisfactory r esults are o btained with high yields, short reaction times, and simplici ty in the ex perimental p rocedure. The catalyst could easily be recycled and reused four times w ithout noticeable decre ase in catalytic activity.

کلیدواژه ها:

Zinc o xide ، Zinc oxide ، oxazole