Hyaluronic acid film surface Nanostrucuring by Laser for cell loading applications: A review

Today, tissue engineering has opened a special place in medicine for repairing damaged tissue. Among others, we can mention the healing of skin wounds caused by injuries and burns. The task of skin tissue engineering is to provide three-dimensional substrates of materials similar to and compatible with the physical and mechanical properties of the skin tissue, which contain cells and skin repair factors. The materials used in the field of skin repair are mostly polymers. It is biocompatible, with the ability to decompose and degrade exposed or inside the damaged tissue. Hyaluronic acid is one of the natural polymers with proper biocompatibility and degradation properties and is one of the main ingredients of the skin tissue. Among the structural requirements of the material used as a substrate, the surface has a specific topography and roughness that is defined in micro and nanometer dimensions. These nanometer porous structures play a role in cell adhesion, proliferation and migration. It is possible to make structural changes on the surface of the substrate material by chemical, physical and biological methods, each method requires defined and pre-designed tools and processes and subsequent evaluations. One of these tools that cause changes in the surface structure is a laser, which by irradiating light photons in a concentrated manner, delivers the energy to the target in the form of light photons. In this study, a review of the application of hyaluronic acid as a substrate in which it is possible to provide nanostructures with the help of a laser tool was done to clarify the effect of the mentioned method and the interaction of cells on the polymer.

کلیدواژه ها:

Hyaluronic acid ، surface nanostructure ، stem cells ، Laser beam.