The effect of Zinc on the Immune responses of pneumococcal vaccination in elderly

Background and Aim: Considering the zinc sulfate as an  immunumedolator in antibody production, the aim of this study was to investigate the effect of zinc sulfate on the immunological response  of pneumococcal vaccines in elderly people over ۶۵. Materials and Methods: In this case-control study in ۲۰۱۲, ۱۲۰ patients (over ۶۵ years old) were selected and randomly divided into two separate equal study and control groups. Pneumococcal vaccine injected with the dose of ۲۳ ppv to study and control group then zinc sulfate supplement capsule taken by the study group and a sugar capsule as a placebo by control group for one month period as well. Blood samples were taken before and one month after vaccination, specific antibody (Ab) level against pneumococcal polysaccharide capsule, was measured with Maxisorb ELISA kit. Then findings interpreted with Stata software version ۸ (sas ver ۸, USA), a t-test was done for assessment of the relationship between independent variables. The effect of zinc, age, smoking and BMI has been assessed on the level of Ab production with regression interpreter. Results and Conclusions: The average increase in antibody levels before and one month after vaccination in the control group, ۴۲.۸۷ ± ۲۵.۲۱ to ۱۱۸.۸۷ ± ۲۹ and in the study group were from ۴۱.۷۶ ± ۲۷.۵۱ to ۱۱۷.۶۶ ± ۳۲.۵۳ units per mL. Zinc, age, sex, BMI and smoking with ۹۵% reliability had no effect on antibody production in both groups. subscription of zinc sulfate for one month period as an immunomodulator after pneumococcal vaccination has no significant effect on the level of antibody production in response to pneumococcal ۲۳ valent vaccines.

کلیدواژه ها:

Vaccination ، Pneumococci ، Zinc ، Antibody ، واکسیناسیون ، پنوموکوک ، روی(zinc) ، آنتی بادی