The Effect of Christ’s Thorn (Ziziphus Spina Christi) Leaves Extract on Lipid Profile, Lipid Peroxidation and Liver Enzymes of Diabetic Rats

Objective: The effect of herbal medicine is more useful than synthetic medicines. The present research paper aims to show the effects of leaves extracts of Zizyphus Spina Christi (ZSC) on lipid profile, lipid peroxidation and activities of aminotransferase enzymes in streptozocin induced diabetic adult male rats. Materials and Methods: Fifty six male rats weighing ۱۵۰-۲۰۰ gm were included in this study. They were divided into ۸ groups. The first group, non-diabetic control rats received distilled water. The second, third and fourth groups, non-diabetic rats were given doses ۵۰ mg/kg body weight (BW), ۷۵ mg/kg (BW) and ۱۰۰mg/kg (BW) ZSC extracts. The fifth group, diabetic control, received distilled water. The sixth, seventh and eighth were given doses, ۵۰mg/kg (BW), ۷۵ mg/kg (BW) and ۱۰۰mg/kg (BW) ZSC extracts. Weight and fasting blood glucose were measured every week and the period of treatment continued for four weeks. Serum lipid profile, malondialdehyde (MDA) and aminotransferase enzymes (AST, ALT) were measured at the end of experiment. Results: In diabetic rats ZSC leaves extract significantly reduced serum total cholesterol, triglyceride, LDL-C, AST (aspartate aminotransferase) and ALT (alanine aminotranferase) (P<۰.۰۵). The serum malondialdehyde markedly decreased (P<۰.۰۰۱), But HDL –C increased significantly (P<۰.۰۵). Conclusion: The present paper revealed that ZCS leaves extract has beneficial effects on lipid profile, lipid peroxidation and aminotranferase enzymes in diabetic rats.

کلیدواژه ها:

Diabetic rats ، Lipid per oxidation ، Lipid profile ، Ziziphus Spina Christi