Anti-Obesity, Fat Lowering and Liver Steatosis Protective Effects of Ferula asafoetida Gum in Type ۲ Diabetic Rats: Possible Involvement of Leptin
محل انتشار: مجله دیابت و چاقی ایران، دوره: 4، شماره: 3
سال انتشار: 1391
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 63
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شناسه ملی سند علمی:
JR_IJDO-4-3_005
تاریخ نمایه سازی: 16 آبان 1402
چکیده مقاله:
Objective: Control of weight gain is an important strategy in reducing the diabetes incidence. Recently, herbal drugs have been used as a complementary and alternative medicinal care. This study was conducted to determine the effect of Ferula asafoetida on weight gain, fat accumulation, liver steatosis and leptin level.
Materials and Methods: All rats of control and treatment groups received daily tap water (P.O) as vehicle mixed with fructose ۱۰%. Two treatment groups received FAF oleo-gum resin at doses of ۲۵ or ۵۰ mg/kg (P.O). Normal rats received only tap water and standard chow food. Body weights, abdominal fat, size of epididymal adipocyte and serum leptin were recorded.
Result: Administration of Ferula asafoetida significantly decreased body weights, abdominal fat and size of epididymal adipocyte compared to untreated rats (P<۰.۰۵). Levels of serum leptin were significantly decreased in treated rats (P<۰.۰۵).
Conclusion: This study showed that Ferula asafoetida extract has anti-obesity, fat lowering effects and can prevent liver steatosis in type ۲ diabetic rats. Reduction of serum leptin is associated with protective effects of Ferula asafoetida in obese diabetic rats.
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نویسندگان
Hossain Azizian
Msc of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
Mohammad Ebrahim Rezvani
Assistant professor of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
Mansour Esmaeilidehaj
Assistant professor of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
Seyyed Majid Bagheri
Msc of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran