Myeloproliferative disorders and its associated mutations

Myeloproliferative Neoplasm (MPN) are a clonal disorder in hematopoietic stem cells (HSC). MPN is categorized to ۸ subclasses, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocytopenia (ET), primary myelofibrosis (PMF), systematic mastositosis (SM), chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia (CNL), and unclassified myelofibrosis disorders (UMPN). It usually occurs in ۵th to ۷th decade of life. However, CNL and ET have been observed in children. A lot of mutations have been identified in these disorders that Jak۲V۶۱۷F is the most important mutation. Moreover, several somatic mutations other than JAK۲V۶۱۷F in MPN patients have been reported. Such mutations include MPL, TET۲, ASXL۱, IDH۱, IDH۲, CBL, LNK, IKZF, and EZH۲ from precursor stem cells. The role of mutations mentioned is not clear in pathogenesis of this disease. Hence, in this study, mutations in different stages of myeloproliferative disorders have been reviewed.

کلیدواژه ها:

MPN ، Hematopoietic stem cells ، Mutation