Electrochemical sensing of Nalbuphine in pharmaceutical samples using amplified MgO/CNTs nanocomposite electrode

MgO/CNTs nanocomposite was synthesized by a simple strategy and used for modification of paste electrode. The paraffin oil (PI) and ۱-Butyl-۳-methylimidazolium methyl sulfate (BMMS) were used as binders for fabrication of MgO/CNTs/PI/BMMS/PE. The results confirm the ۹% w:w of MgO/CNTs showed high catalytic activity on nalbuphine signal and this value was used as optimum condition for fabrication of sensor. The MgO/CNTs/PI/BMMS/PE introduce as new analytical sensor for determination of nalbuphine in the concentration range ۱.۰ nM– ۴۰۰ µM with detection limit ۰.۵ nM. In final step, the MgO/CNTs/PI/BMMS/PE was used for monitoring of nalbuphine in injection and serum samples with acceptable recovery data.MgO/CNTs nanocomposite was synthesized by a simple strategy and used for modification of paste electrode. The paraffin oil (PI) and ۱-Butyl-۳-methylimidazolium methyl sulfate (BMMS) were used as binders for fabrication of MgO/CNTs/PI/BMMS/PE. The results confirm the ۹% w:w of MgO/CNTs showed high catalytic activity on nalbuphine signal and this value was used as optimum condition for fabrication of sensor. The MgO/CNTs/PI/BMMS/PE introduce as new analytical sensor for determination of nalbuphine in the concentration range ۱.۰ nM– ۴۰۰ µM with detection limit ۰.۵ nM. In final step, the MgO/CNTs/PI/BMMS/PE was used for monitoring of nalbuphine in injection and serum samples with acceptable recovery data.

کلیدواژه ها:

Nalbuphine ، MgO/CNTs nanocomposite ، Ionic liquid ، drug monitoring