BACKGROUND AND ABJECTIVEAntimicrobial resistance, a growing global problem, is recognized as one of the main causes of mortality around the world. In transplant recipients, multidrug-resistant pathogens are associated with significant complications despite advanced surgical techniques, the development of immunosuppressive drugs, antibiotics, vaccines, and infection control measures. Therefore, the aim of this study was to investigate the antibiotic resistance profile of
Pseudomonas spp. isolated from transplant and non-transplant patients in Abu-Ali-Sina hospital of Shiraz.MATERIALS AND METHODSIn a cross-sectional study,
Pseudomonas spp. were isolated from different clinical samples during a period of ۶ months. The strains were identified by standard microbiological tests. Antimicrobial sensitivity test was performed using the Kirby-Bauer disk diffusion method, according to the CLSI guideline. Finally, the data were analyzed using the Statistical Package for the Social Sciences software (SPSS, version ۲۵.۰).RESULTS AND DISCUSSIONIn total, during this study, ۴۹ clinical isolates of
Pseudomonas spp. were isolated from transplant ۲۱(۴۲/۹%) and non-transplant ۲۸(۵۷/۱%) patients. In transplant patients, the most isolation was related to liver transplant ۱۱(۲۲/۴%), followed by kidney transplant ۹(۱۸/۴%). The highest and lowest bacterial isolates in both groups were obtained from sputum ۱۵(۳۰/۶%), urine ۱۳(۲۶/۵%) and blood ۵(۱۰/۲%) samples, respectively. In non-transplant patients, the highest resistance rate was related totrimethoprim/sulfamethoxazole(۹۲/۹%), doxycycline(۸۹/۳%), levofloxacin(۶۰/۷%), ciprofloxacin(۵۷/۱%), meropenem(۵۳/۶%), ceftazidime(۵۰%) and the least resistance was related to colistin(۷/۱%) and piperacillin-tazobactam(۳۵/۷%). In transplant patients, the highest resistance rate was related totrimethoprim/sulfamethoxazole(۱۰۰%), doxycycline(۹۵/۲%), ciprofloxacin(۷۶/۲%), levofloxacin(۷۶/۲%), meropenem(۷۶/۲%), piperacillin-tazobactam(۷۱/۴%), gentamicin (۷۱/۴%), ceftazidime (۶۶/۷%) and the least resistance was related to colistin(۰%).CONCLUSIONConsidering that strains isolated from transplant patients had higher resistance to the investigated antibiotics, thus, applying the best policies and strategies to reduce antibiotic resistance and strengthen rational antibiotic treatment is essential in these patients.