Clinical Syndromes in HIV/AIDS according to CD4 count

Immunodeficiency duo to HIV infection can produce unusual diseases in infected individuals & CD4 count is the main predictor of disease progression. In this studyclinical syndromes resulting in admition, are considered according to CD4 count for the beter diagnosis and treatment of clinical problemes in HIV infected patients.Materrial & Methods: This is a cross - sectional study that was performed since March 2002 to March 2003 in Kermanshah Sina Hospital. HIV infection was confirmed with positive duble ELISA and Western Blot. CD4 count was measured by flucytometery, clinicalsyndromes were collected with final diagnosis, and the rest of the data were gathered according to the patients' interviews. Statistical analysis was performed by SPSS 11.5.Results: During this study, 72 out of 215 admssions were enrolled. All of them were male with the mean age of 33.4 9.1 years. 64 cases (88.9%) were addicted and 40 cases (55.6%) had prison history. Clinical and/or laboratory indicators of AIDS were observed in 32 cases(44.4%). The average of CD4 count was 356/μL.Patients with lymphadenopathy, neurologic and pneumonia syndromes had the least count of CD4 with the averages of 90, 241 and 269/μL and patients with sepsis , endocarditis and hepatitis syndromes had the highestCD4 average count of 646, 394 and 373/μL respectively. Statistically correlations were observed between pneumonia syndrome with CD4<200/μL(Pvalue=0.005), and addictionhistory(Pvalue =0.0001). Suffering from hepatitis syndrome was also statistically correlatedwith being at prison. Conclusion: High prevalence of AIDS in our study was a trait which means high prevalence of asymptomatic HIV infection in general population .Also in patients with CD4<200/μL,especially those who are addicted, pneumonia syndrome may occur. Lymphadenopathy, neurologic and pneumonia syndromes are more common in CD4<300/μL whereas sepsis, Endocarditis and hepatitis syndromes are common in CD4> 300/μL, that shows the effectof CD4 count in appearance of clinical syndrpmes. Unsafe injections in prisons may cause acquisition of viral hepatitis in these patients.

کلیدواژه ها:

HIV ، CD4 ، Clinical Syndromes