Fabrication of polymeric film using electrospun nanofibersfor sublingual delivery of rizatriptan

Migraine is a hereditary headache that is prevalent all over the world among women between 25 to 55 years old. There is no known treatment is available for a complete cure for this disorder. In this study we proposed polymeric electrospun nanofiber mat as drug carrier for sublingual drug delivery of antimigraine drug—rizatriptan. PVP were used as the polymer. In this study we investigated the applicability of this method by in-vitro examination. The results demonstrated that all incorporated drugs can be easily released to the medium within 4 minutes which is high enough for using as sublingual drug delivery film as a migraine headache pain reliever

کلیدواژه ها:

electrospinning ، migraine ، sublingual rout of administration